丸激素治疗会影响跨性别个体的肠道微生物群
Rebecca M Harris1,2, Fernanda Pace3, Thomas M Kuntz4
1Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
mSphere
|September 10, 2024
概括
变性人群的丸激素治疗改变了肠道微生物群,特别是增加产生谷氨酸的途径,减少消耗谷氨酸的途径. 这表明宿主-微生物相互作用影响营养的可用性.
科学领域:
- 微生物组研究的研究.
- 内分泌学 在内分泌学.
- 跨性别者健康问题
背景情况:
- 性激素,如丸激素,影响整体健康,并且在医学上对各种疾病进行调节.
- 肠道微生物群与性激素双向相互作用.
- 外源性对肠道微生物群的影响尚不清楚.
研究的目的:
- 研究外源性丸激素治疗对跨性别个体肠道微生物群的影响.
- 分析与氨基酸代谢相关的微生物途径的变化.
主要方法:
- 从9名跨性别者收集了26个便样本,这些样本是在开始丸激素治疗之前和8个月后收集的.
- 在便样本上进行了基因组学分析,以评估微生物组的组成和功能.
- 分析了微生物通路的变化,特别是那些涉及谷氨酸的变化.
主要成果:
- 没有发现物种丰富度和丸激素治疗持续时间之间的显著关联.
- 增加产生谷氨酸酸的途径的丰富性.
- 减少消耗谷氨酸的途径的丰富性.
结论:
- 丸激素疗法对肠道微生物群落结构的影响很小.
- 丸激素治疗增加了谷氨酸生成途径,并减少了肠道微生物群中的谷氨酸消耗途径.
- 建议的机制:丸激素可能会增加宿主对氨酸的吸收以合成氨酸,从而减少其对微生物群的可用性.
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