在神经发育条件下,与与年龄相关的大脑结构和功能变化相关的数据集因素
Marlee M Vandewouw1,2, Yifan Julia Ye1,3, Jennifer Crosbie4,5
1Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Human brain mapping
|September 10, 2024
概括
与年龄相关的大脑变化在神经成像数据集之间有所不同. 在神经发育研究中,皮质表面积和功能连接的差异与种族/种族和头部运动有关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 在神经成像中,年龄至关重要,特别是在神经发育条件下.
- 大数据集检查神经类型和神经分离个体的大脑变化.
- 跨数据集的与年龄相关的大脑变化的一致性尚不清楚.
研究的目的:
- 在两个神经多样性数据集中建模与年龄相关的大脑结构和功能.
- 为了研究与年龄相关的大脑变化的数据集差异.
- 探索偏差与人口统计/临床变量之间的关联.
主要方法:
- 建模了与年龄相关的皮质厚度,表面积 (N=1218) 和功能连接 (N=1254).
- 利用了来自安大略省神经发育网络和健康大脑网络的数据.
- 检查了数据集偏差及其与人口和临床因素的相关性.
主要成果:
- 在皮质表面积和功能连接方面发现了显著的数据集差异.
- 皮层表面积差异与种族/种族相关.
- 与头部运动相关的功能连接差异.
结论:
- 与年龄相关的大脑变化在神经成像数据集中并不总是一致的.
- 人口 (种族/种族) 和表型 (头部运动) 因素影响了这些变化.
- 未来的研究必须在神经发育研究中分析年龄影响时考虑这些因素.
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