美国饮用水中的消毒副产品和癌症死亡率
1Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
International journal of environmental health research
|September 10, 2024
概括
饮用水消毒的副产品,总三甲 (TTHM),可能会增加癌症风险. 这项研究发现,饮用水中的TTHM,甲和二甲与较高的癌症死亡率有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 三甲 (THM) 是饮用水中的主要消毒副产品.
- 一些THM被怀疑是致癌物,并且在美国受到监管 (最高80μg/l TTHM).
- THM暴露与癌症死亡率之间的关联需要进一步调查.
研究的目的:
- 研究美国饮用水中的总和个体三甲与癌症死亡率之间的关联.
- 评估美国成年人癌症死亡率的潜在风险因素.
主要方法:
- 利用了来自6,260名国家健康和营养检查调查参与者的数据 (1999-2008),并对死亡率进行了到2019年的随访.
- 采用Cox的比例危险回归,对相关的共变量进行调整.
- 在饮用水中分析了总三甲 (TTHM),和二甲水平.
主要成果:
- 总共记录了873例死亡,其中包括207例癌症死亡,平均随访时间为14.4年.
- 高水平的TTHM (HR: 1.45,95% CI: 1.16-1.82) 与癌症死亡率的增加有关.
- 特定的THM, (HR: 1.35,95% CI: 1.12-1.64) 和二甲 (HR: 1.30,95% CI: 1.05-1.59) 显示出与更高的癌症死亡率 (30-45%的增加) 有显著的关联.
结论:
- 饮用水中的三甲,特别是甲和二甲,可能是癌症死亡的风险因素.
- 调查结果表明,饮用水中THM暴露可能引起公众健康问题.
- 需要进一步的研究来证实这些关联,并探索缓解策略.
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