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超加工食品,过敏结果和儿童的潜在机制:EAACI工作组的报告
Roberto Berni Canani1,2,3,4, Laura Carucci1,2, Serena Coppola1,2
1Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
概括
超加工食品 (UPF) 的消费与儿童过敏的更高风险有关,包括喘和食物过敏. 需要进一步的研究来证实这种联系,并了解涉及的机制.
科学领域:
- 儿科过敏和免疫学
- 营养流行病学 营养流行病学
- 环境健康 环境健康
背景情况:
- 超加工食品 (UPF) 的消费是一个日益严重的公共卫生问题,可能与不良健康结果有关.
- 关于UPF摄入量与儿童发生过敏疾病之间的关联的证据有限.
- 在UPF和过敏之间存在任何潜在联系的基础上的生物机制在很大程度上仍未被探索.
研究的目的:
- 系统地审查和综合现有关于超加工食品消费与儿科过敏结果之间的关联的文献.
- 探索肠道微生物组和免疫系统在调解UPF和过敏之间潜在联系方面的作用.
主要方法:
- 按照PRISMA指南进行了系统审查和叙事证据综合.
- 该审查包括26篇论文,检查了UPF消费和儿科过敏结果.
- 分析结合了研究,研究UPF对肠道微生物群 (16篇论文) 和免疫系统 (3篇论文) 的影响.
主要成果:
- 饮食中摄入果糖,糖和含糖饮料与喘,过敏性鼻炎和食物过敏的风险增加有关.
- 商业婴儿食品和各种UPF成分 (如单谷氨酸,先进的糖化最终产品) 的消费与过敏疾病的发生相关.
- 总的来说,UPF及其常见成分似乎与过敏性疾病的发病率较高有关,包括亚托皮炎和喘息,尽管研究结果并非在所有研究中普遍存在.
结论:
- 需要进一步的临床前和临床研究来阐明UPF消费与过敏和喘风险之间的关系.
- 未来的观察性研究应该包含明确定义的UPF摄入量,经过验证的饮食评估和机制性评估,以加强证据基础.
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