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Updated: Jun 13, 2025

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
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对于GLP-1R抗原剂表胺衍生物的功能和稳定性TRP-Cage的影响

Dániel Horváth1,2, Pál Stráner1,2, Nóra Taricska1,2

  • 1HUN-REN-ELTE Protein Modeling Research Group, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest H-1117, Hungary.

Journal of medicinal chemistry
|September 10, 2024
PubMed
概括

埃克西纳提德的结构会影响其治疗糖尿病和肥胖的有效性. 稳定其Trp-cage动图增加了稳定性,但通过干扰受体结合和信号传导来降低生物活性.

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