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开发和验证对比增强的美国VI-RADS用于评估膀癌肌肉入侵

Jing Han¹, Min Lin¹, Qingguang Lin¹

¹From the Departments of Ultrasound (J.H., M.L., Q.L., R.G., Y.L., Z.G., L.L., J.Z.) and Urology (Z.W., Y.Y., K.Y.), Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, No. 651 Dongfeng Rd East, Guangzhou 510060, People's Republic of China.

|September 10, 2024

概括

一个新的对比增强的美国 (CEUS) 膀成像报告和数据系统 (VI-RADS) 已开发,以评估膀癌的肌肉入侵. 该系统表现出良好的诊断性能和读者对评估膀癌入侵的认同.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
瘤成像学成像学
医疗器械和仪器仪表医疗器械和仪器仪表

背景情况:

与对比度增强的超声波 (CEUS) 对于在膀癌中进行肌肉侵袭的术前评估是有价值的,对于治疗计划至关重要.
目前缺乏用于评估膀癌肌肉入侵的CEUS标准诊断标准.

研究的目的:

开发和验证CEUS膀成像报告和数据系统 (VI-RADS),用于标准化评估膀癌的肌肉入侵.
建立最佳标准并评估CEUS VI-RADS.的诊断性能和读者间协议.

主要方法:

一项前性,单中心研究招募了疑似膀癌的患者接受CEUS.
使用一个训练套件 (2:1比) 来制定CEUS VI-RADS标准,识别关键的成像特征并确定肌肉入侵的最佳切断.
初学者和专家读者使用一个验证集来评估诊断性能和与病理学参考标准之间的互读者协议.

主要成果:

在训练组中,肌肉入侵的最佳切断点是CEUS VI-RADS类别4或更高 (尤登指数,0.77).
在验证组中,CEUS VI-RADS在初学者和专家读者之间显示出良好的诊断性能 (AUC分别为0.80和0.88).
对于CEUS VI-RADS分类的读者之间的共识很大,在读者群体之间从0.77到0.87不等.

结论:

开发的CEUS VI-RADS提供了一种标准化的方法,用于评估膀癌的肌肉入侵.
该系统表现出良好的诊断准确性和可靠的读者间一致性,有助于术前评估和治疗决策.

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