在CRSwNP患有嗅觉障碍的患者中,术后未恢复的嗅觉功能的预测模型
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou, China; Department of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou, China; Key Laboratory of Airway Inflammatory Disease Research and Innovative Technology Translation, Guangzhou, China.
Rhinology
|September 10, 2024
概括
长期鼻炎与鼻息肉 (CRSwNP) 中的嗅觉障碍 (OD) 经常在手术后持续存在. 低的嗅觉障碍-消极陈述 (QOD-NS) 预手术前问卷得分和组织乙素细胞计数预测嗅觉结果不佳.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 嗅觉功能障碍研究研究
背景情况:
- 嗅觉障碍 (OD) 是慢性鼻炎与鼻 (CRSwNP) 的常见和困难症状.
- 内镜外科手术 (ESS) 是CRSwNP的治疗方法,但嗅觉结果可能是可变的.
- 在CRSwNP患者中预测ESS后的恶性嗅觉预后对于OD患者的管理至关重要.
研究的目的:
- 在CRSwNP患者中确定ESS后持续性嗅觉障碍的危险因素.
- 开发一个预测模型,用于这个患者群体的恶性嗅觉预后.
主要方法:
- 研究了78名CRSwNP患者,他们接受了ESS的OD.
- 嗅觉功能在术前和术后6个月使用Sniffin' Sticks进行了评估.
- 使用后勤回归和ROC曲线来识别风险因素并开发预测模型.
主要成果:
- 66.7%的患者在ESS后6个月内没有恢复嗅觉.
- 较低的嗅觉障碍 - 消极陈述 (QOD-NS) 预手术问卷得分,较低的嗅觉裂总得分 (TOCS) 和较少的组织埃索诺菲尔与未恢复的嗅觉有关.
- 一个结合QOD-NS,TOCS和异osinophil数量的预测模型实现了0.845.5的AUC.
结论:
- 在手术前的QOD-NS,TOCS和组织乙氨基酸细胞计数是CRSwNP中短时间的嗅觉功能障碍后ESS的独立风险因素.
- 开发的预测模型对于早期识别臭味预后不佳的患者来说是实用的.
- 早期识别可以及时进行额外的干预,以改善嗅觉结果.
相关概念视频
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...


