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Updated: Jun 13, 2025

A Purification and In Vitro Activity Assay for a pppGpp Synthetase from Clostridium difficile
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伊诺西二酸盐类似物作为Clostridioides difficile毒素B的Allosteric激活剂的结构-活性关系

Rebecca Cummer1, Félix Grosjean1, Raphaël Bolteau1

  • 1Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada.

Journal of medicinal chemistry
|September 10, 2024
PubMed
概括

新的伊诺西-基酸盐 (IP6) 类似物在肠道光线中准Clostridioides difficile毒素. 这些类似物在进入细胞之前诱导毒素分解,防止感染病原性.

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