在撒丁岛的肌性侧面硬化症队列中,Takotsubo综合征
A Maccabeo1, M I Pateri2, F Pili3
1Department of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy. alessandramaccabeo@outlook.it.
Journal of neurology
|September 10, 2024
概括
塔科特苏博综合征 (TTS) 影响1.45%的肌缩性侧面硬化症 (ALS) 患者,特别是患有晚期囊泡干扰的女性. 触发因素经常被确定,但在ALS中TTS的确切原因需要进一步研究.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 肌缩侧面硬化症 (ALS) 与自主和心血管功能障碍有关.
- 最近的报道表明,ALS和Takotsubo综合征 (TTS) 之间存在潜在的联系.
- 了解这种关联对于管理ALS患者至关重要.
研究的目的:
- 为了确定TTS的频率,在一个发生的队列的肌缩性侧面硬化症 (ALS) 患者.
- 调查TTS和ALS进展之间的关系.
- 确定ALS患者TTS的潜在风险因素和触发因素.
主要方法:
- 来自意大利撒丁岛的10年ALS事件队列 (2010-2019) 的回顾性分析.
- 在ALS队列中评估TTS频率和患者临床特征.
- 在2019年以后发病的ALS患者中对TTS的后续调查.
主要成果:
- 在344名 (1.45%) 的发生ALS患者中,有5名患有TTS.
- 所有TTS病例发生在女性患者身上,中位数发病年龄为71.5岁.
- 在TTS诊断时,患者呈现了晚期疾病 (囊干扰,ALSFRS ≤25).在三个病例中确定了触发因素.
结论:
- 塔科茨博综合征 (TTS) 在肌缩性侧面硬化症 (ALS) 患者中并不罕见.
- 女性的性别,凸骨ALS发病率和晚期疾病发病年龄是TTS的潜在风险因素.
- 经常观察到身体或心理触发因素,但潜在的病理生理学需要进一步调查.
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