补体系统的激活:桥梁生理学,病理生理学和治疗
Elie Azoulay1, Julien Zuber2, Ahmed Aziz Bousfiha3,4,5
1Intensive Care Unit, Saint-Louis University Hospital, AP-HP, Paris Cité University, Paris, France. elie.azoulay@aphp.fr.
Intensive care medicine
|September 10, 2024
概括
补体系统对免疫力至关重要,但过度激活会导致疾病. 有效的抑制剂存在于非典型的血溶性尿素性综合征和肌痛性肌痛症等疾病,尽管需要更多的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 病理生理学 病理生理学
背景情况:
- 补体系统包括50多种蛋白质,是先天免疫的组成部分,涉及蛋白质溶解级联.
- 补体系统激活的失调在诸如败血症和急性呼吸困扰综合征等疾病中具有病原性.
- 过度的补体激活会导致组织损伤,炎症和毛细血管泄漏,可能会恶化严重的COVID-19.
研究的目的:
- 审查正常的补体系统及其在严重疾病中的失调.
- 讨论非典型的血溶性尿素性综合征 (aHUS) 和严重骨髓质疏松症的补充过度激活.
- 突出补充抑制疗法的有效性和挑战.
主要方法:
- 关于补充系统功能和失调的科学文献的综述.
- 分析补充剂在严重疾病和特定自身免疫性疾病中的作用.
- 讨论诊断方法和治疗策略,包括补充抑制剂.
主要成果:
- 补充剂过度活化与败血症,ARDS,严重的COVID-19,aHUS和严重肌痛症有关.
- 早期补充抑制是有效的,eculizumab和ravulizumab是关键疗法.
- 补充抑制剂的预防性使用可以防止移植后HUS复发.
结论:
- 补体系统是必不可少的,但其过度激活会导致严重的疾病.
- 有效的补充抑制剂可用,但最佳使用和个性化治疗需要进一步研究.
- 需要先进的诊断和治疗标志物,以更好地进行补充介导疾病管理.
关键词:
急性呼吸困扰综合征是什么非典型的血溶性尿性综合征补充激活的激活方式补充系统蛋白质的补充危急的疾病 危急的疾病骨髓灰质炎 (Myasthenia gravis) 是一个严重的疾病.败血症 这是一种败血症.严重的COVID-19 疾病更多相关视频
06:29Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
30.6K
07:25In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
17.7K
相关概念视频
01:27Complement System
2.3K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.3K
01:23Antimicrobial Proteins
950
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
950
01:28Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
01:26Antibody Actions
1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
01:36Humoral Immune Responses
72.2K
Overview
72.2K
01:24B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K