循环的毛囊辅助T细胞的两极化与毛囊皮虫的严重程度相关
Corine Pérals1, Sébastien le Jan2, Céline Muller2,3
1Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM U1291, CNRS U5051, University Toulouse III, Toulouse, France.
The British journal of dermatology
|September 10, 2024
概括
球状皮炎 (BP) 患者表现出改变的循环毛囊辅助T (Tfh) 细胞,这些细胞通过局部皮质类固醇 (TCS) 治疗得到改善,但保持了活性表型,这表明Tfh细胞在BP病理生理学中的两极化.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 毛囊辅助T细胞 (Tfh) 调节幽默免疫,并与B细胞介导的自身免疫性疾病有关.
- 球状皮炎 (BP) 是一种由对半球体蛋白的自身抗体驱动的水泡性皮肤疾病.
研究的目的:
- 评估强效局部皮质类固醇 (TCS) 治疗对血压患者循环Tfh细胞的影响.
- 为了比较Tfh细胞频率,极化和激活在血压患者与对照患者,并在TCS治疗期间纵向进行.
主要方法:
- 流细胞计用于分析循环的Tfh细胞群.
- 从血压患者和年龄/性别匹配的对照组在基线和TCS治疗期间采集了血液样本.
主要成果:
- 与对照人群相比,BP患者在基线时循环Tfh细胞的频率和激活增加.
- Tfh细胞偏向向17型转移,Tfh亚群比率与BP疾病严重程度相关.
- 通过TCS治疗,Tfh细胞的频率降低到控制水平,但激活的表型仍然存在;血清IL-21和自身抗体减少.
结论:
- Tfh细胞两极化参与了型类动物的病理生理学.
- 调节Tfh细胞活动为BP提供了潜在的治疗策略.
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