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Updated: Jun 13, 2025

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衰老的纤维细胞衍生的细胞外囊泡在黑色素瘤中促进血管生成

Laura Hüser1, Yash Chhabra2, Olesia Gololobova3

  • 1Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.

Cell reports
|September 10, 2024
PubMed
概括

衰老会改变皮肤中的细胞外囊泡 (EVs),减少CD9蛋白,增加ANGPTL2. 这些老年EVs促进血管生长,可能会恶化黑色素瘤的进展.

关键词:
在CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9CP: 癌症 癌症 癌症老化的老化 衰老的老化血管素连接体2 (ANGPTL2) 的作用.血管新生是因为血管新生.外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.纤维细胞的细胞.黑色素瘤是一种黑色素瘤.

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