瓶装海豚中CeFPODOXIME的人口药动力学 (TURSIOPS TRUNCATUS) 在瓶装海豚中
Barbara K Linnehan1, Steven P Lesman2, Joseph F Boucher2
1National Marine Mammal Foundation, San Diego, CA 92106, USA, barb.linnehan@nmmf.org.
概括
在瓶鼻海豚中,Cefpodoxime Proxetil的药理动力学数据显示,其半衰期比其他物种更长. 这项研究为优化鱼的抗生素剂量提供了关键信息,有助于兽医治疗决策.
科学领域:
- 兽医药理学 兽医药理学
- 海洋哺乳动物医学 海洋哺乳动物医学
- 抗微生物药物的药理动力学
背景情况:
- 塞夫多克西姆普罗克塞蒂尔是一种广泛用于治疗鱼细菌感染的抗生素.
- 仅有有限的药理动力学数据可指导海豚中最佳的塞夫多克西姆前剂量.
- 了解海洋哺乳动物的药物行为对于有效治疗至关重要.
研究的目的:
- 为了评估cefpodoxime proxetil在瓶鼻海豚 (Tursiops truncatus) 中的人口药理动力学.
- 在这种物种中确定 cefpodoxime proxetil 的药理学参数.
- 为海豚提供基于证据的抗微生物剂量策略.
主要方法:
- 稀少采样的药理动力学研究设计.
- 每24小时服用10毫克/千克的塞夫多克西姆普罗克塞蒂尔口服.
- 使用液体染色学-质谱学分析血清样本.
- 用非线性混合效应建模进行人口药理动力学分析.
主要成果:
- 一个双隔间模型最好地描述了 cefpodoxime 的药理动力学.
- 平均最大度 (Cmax) 为23.0μg/ml,Cmax的时间为5.0小时,半衰期为11.4小时.
- 药物积累量约为18%,每日剂量;稳定状态达到第二剂量.
- 血清蛋白的结合率为82.8%.
结论:
- 每天服用一次口服塞夫多克西姆西,被系统吸收,在海豚中迅速达到最大度.
- 观测到的海豚半衰期比其他物种更长.
- 这些发现支持针对瓶鼻海豚细菌感染的抗微生物选择和剂量.
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