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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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相关实验视频

Updated: Jun 13, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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一个如何指导生物中的代码共享的指南.

Richard J Abdill1, Emma Talarico2, Laura Grieneisen2,3

  • 1Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.

PLoS biology
|September 10, 2024
PubMed
概括

计算生物学对于现代生物研究至关重要. 本指南为生物学家提供了关于共享计算代码,促进开放科学原则和可重复性的实用建议.

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科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 在生物学的开放科学.

背景情况:

  • 生物学越来越依赖计算分析,湿实验室研究人员采用新的技术.
  • 由于成本下降和数据集的增加,计算工具的可访问性正在增加.
  • 实施计算方法的指导比报告它们的指导更容易获得,从而造成知识差距.

研究的目的:

  • 为生物学家提供关于计算代码共享最佳实践的全面指南.
  • 为应对新研究人员面临的挑战,在计算生物学中开放科学原则.
  • 弥合计算方法实施和透明报告之间的差距.

主要方法:

  • 对计算机生物学和代码共享现有文献的审查.
  • 汇总了报告计算工作的常见提示和最佳实践.
  • 编译资源用于培训计算生物学和开放科学.

主要成果:

  • 确定生物学家在计算代码共享方面面临的关键挑战.
  • 为有效共享代码制定实际建议.
  • 策划相关的资源,用于进一步的学习和培训.

结论:

  • 生物学家需要对共享计算代码的明确指导,以采用开放科学原则.
  • 实施代码共享的最佳实践可以提高研究的透明度和可重复性.
  • 这本指南是寻求改善其计算工作流程的生物学家的起点.