系列多血设计具有双激活,用于患有心力衰竭的儿童患者
Thomas C Palazzolo1, Harutyun Sarkisyan1, Giselle C Matlis1
1From the BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.
概括
这项研究介绍了德雷克塞尔双龙VAD,这是一种具有双系统的新型儿科心室辅助装置 (VAD). 计算和体外试验验证实了它的设计,显示了改善儿科心脏支持的前景.
科学领域:
- 生物医学工程 生物医学工程
- 儿童心脏病学 儿童心脏病学
- 医疗器械开发 医疗器械开发
背景情况:
- 儿科心室辅助器械 (VAD) 的发展落后于成人选择,影响患者的治疗结果.
- 一种新的连续流量,双血VAD正在开发中,以弥补这一缺口.
- 该设备集成了轴向和离心,用于适应儿科循环支持.
研究的目的:
- 为了完善一个新的儿科VAD的设计,德雷克塞尔双龙VAD.
- 用计算方法和体外试验来分析和改进设备的流通路径.
- 为了评估原型的压力流量生成,流体应力和血液损伤潜力.
主要方法:
- 计算流体动力学 (CFD) 使用切削应力传输 (SST) 模型进行流路分析.
- 一种原型器件的体外液压测试.
- 估计压力流,液体标尺应力和血液损伤水平.
主要成果:
- 试验室液压测试显示与SST预测有很好的相关性 (平均偏差为4.5%).
- 该设备的性能遵循预期的趋势.
- 刀片尖端清除处的血液损伤水平超过了目标,需要进一步调查.
结论:
- 该研究验证了德雷克塞尔双龙VAD的设计基础.
- 计算和体外数据支持该设备在儿科循环辅助方面的潜力.
- 需要进一步的设计代来解决特定区域的血液损伤.
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