验证EncephalAppStroop测试用于诊断罗马尼亚人口中最小肝脏脑病的诊断
Ioan Cristian Lupescu1, Speranța Maria Iacob2, Corina Pietrăreanu2
1Neurology Department, Fundeni Clinical Institute, Bucharest; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristian.lupescu@drd.umfcd.ro.
Journal of gastrointestinal and liver diseases : JGLD
|September 10, 2024
概括
EncephalApp Stroop 测试可以有效地诊断肝硬化患者的最小肝脑病变 (MHE). 绩效与年龄和肝病严重程度有关,但与教育或疾病持续时间无关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 最小肝脑病变 (MHE) 是肝脑病变的最早期阶段,由于其微妙的表现,经常被忽视.
- MHE显著损害生活质量,工作表现,并导致肝硬化患者过早退休.
- 早期诊断MHE对于肝硬化患者的及时干预和管理至关重要.
研究的目的:
- 评估EncephalApp Stroop测试作为肝硬化患者中MHE的诊断工具.
- 确定Stroop测试性能与临床/实验室参数之间的相关性,包括年龄,教育,肝病严重程度 (MELD,Child-Pugh) 和并发症.
主要方法:
- 一项涉及100名成年肝硬化患者和45名健康对照者的横截面研究.
- 患者和对照组接受了MHE评估的EncephalApp Stroop测试.
- 数据分析探讨了Stroop测试结果与各种临床,人口和实验室因素之间的相关性.
主要成果:
- 与健康对照组相比,肝硬化患者的Stroop测试表现明显较差 (p<0.0001).
- 斯特鲁普测试结果与MELD (R=0.28,p=0.005) 和Child-Pugh分数 (R=0.2,p=0.04) 呈正相关性,表明疾病严重程度增加的表现较差.
- 较差的表现与老年,酒精性肝病,糖尿病,高血糖,贫血和低血症有关. 教育和疾病持续时间没有显著影响.
结论:
- EncephalApp Stroop Test是一种快速而简单的方法,用于在医院环境中诊断MHE.
- 测试性能主要受患者年龄和肝病严重程度的影响.
- 贫血,低血和高血糖等因素也会影响Stroop测试结果,强调MHE呈现的多因素性质.
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