在选择性消毒副产品和消毒的二次废水中非添加性细胞毒性
Yuehao Zhan1, Xuefeng Zeng1, Wenhai Chu2
1Guangdong Engineering Technology Research Center of Water Security Regulation and Control for Southern China, School of Civil Engineering, Sun Yat-sen University, Guangzhou 510275, China.
水消毒副产品 (DBPs) 呈现出非添加性细胞毒性,挑战了典型的毒性研究假设. 相互作用取决于化学物质的类型,度和混合比,需要进一步的研究.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 水处理 处理水的方法
背景情况:
- 消毒副产品 (DBPs) 在经过处理的水中很常见.
- 毒性研究通常假定DBP之间存在添加性相互作用.
- 现有的模型可能不能准确地反映现实世界DBP混合物毒性.
研究的目的:
- 为了研究常见的水消毒副产品 (DBPs) 的非添加性细胞毒性相互作用.
- 评估化学物质类型,度和混合比对DBP细胞毒性的影响.
- 为了比较自下而上的和自上而下的DBP混合物毒性方法的发现.
主要方法:
- 从下而上的方法:在二进制混合物中评估六种常见DBP的细胞毒性.
- 上向方法:使用差异溶剂极性从消毒的二次废水中分成的DBPs.
- 使用组合指数 (CIs) 对不同度和混合比率的量化相互作用.
主要成果:
- 在低度下显示出明显的非添加性细胞毒性 (协同作用和对抗作用).
- CI值因DBP类型,度因子和混合比率而有显著差异.
- 自下而上的CI范围从0.69 (协同作用) 到1.61 (对抗作用).
- 上下分析显示CI值在0.89 (轻微协同作用) 到1.68 (对抗作用) 之间.
结论:
- DBP的细胞毒性是无添加的,并且高度依赖于混合物成分和度.
- 当前的添加模型可能低估或高估DBP风险.
- 需要进一步的研究来确定驱动混合物毒性的关键DBP,并为风险评估提供信息.
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