与静脉血栓栓塞相关的风险因素和死亡率在美国老年人中与慢性淋巴细胞白血病相关
Ambarina S Faiz1, Shuang Guo1, Ashwin Sridharan1
1Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Leukemia research
|September 10, 2024
概括
在慢性淋巴细胞白血病 (CLL) 患者中,静脉血栓栓塞 (VTE) 风险因素因种族不同而有所不同. 识别这些差异可以帮助确定有针对性的VTE预防策略的高风险个体.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症患者患病和死亡的重要原因.
- 在不同种族群体的慢性淋巴细胞白血病 (CLL) 患者中,VTE的特定风险因素尚未得到充分确定.
研究的目的:
- 调查与白色,黑色和亚洲患者的VTE相关的风险因素和死亡率,这些患者被诊断患有CLL.
- 在CLL人口中确定VTE风险和结果的种族差异.
主要方法:
- 利用美国SEER-Medicare数据库从2000年到2015年,专注于65岁及以上的CLL患者.
- 使用后勤回归来分析VTE风险因素和考克斯比例回归来评估VTE对种族队列死亡率的影响.
主要成果:
- 在34,075名CLL患者中,静脉瘤发病率为11.6% (白人),14.6% (黑人) 和6.3% (亚洲人).
- 与白人患者相比,黑人患者的VTE风险更高 (ORa=1.2),亚洲患者的风险更低 (ORa=0.5).
- 贫血和心力衰竭是所有群体中常见的静脉瘤风险因素;高血压和化疗也在白人和黑人患者中显著. VTE与增加的死亡率存在微不足道的关联.
结论:
- 白人,黑人和亚洲CLL患者之间存在VTE风险因素的显著差异.
- 在CLL患者中,VTE与死亡率存在边际关联.
- 调查结果有助于在各种CLL种群中识别高风险个体,以进行主动的VTE管理.
相关概念视频
01:27Disorders of Leukocytes
910
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
910
01:26Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
01:24Disorders of Hemostasis
740
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
740