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暴露于第三手烟雾会促进小鼠和人类的胃瘤发展

Chengfei Jiang¹, Lingyan Chen¹, Chunping Ye²

¹Department of Gastroenterology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Environment international

|September 10, 2024

概括

第三手烟 (THS) 暴露显著增加了小鼠的胃癌风险和瘤发展. 通过激活上皮质-介质酶过渡 (EMT) 途径,THS促进癌症,突出显示室内污染问题.

科学领域:

环境健康环境健康
在瘤学瘤学.
毒理学毒理学毒理学

背景情况:

第三手烟 (THS) 是一种公认的室内污染物,具有潜在的健康风险.
THS的致癌作用和机制,特别是关于胃癌 (GC),需要进一步研究.

研究的目的:

在小鼠模型中研究短期THS暴露对胃癌发展的影响.
探索THS诱导的胃癌发生背后的分子机制,包括基因表达变化和通路激活.

主要方法:

利用自发性胃癌小鼠模型 (CC036) 来评估THS暴露后的瘤发病率和存活率.
在胃上皮细胞上进行RNA测序,以识别THS响应基因表达特征.
用THS在体外治疗人类GC细胞系,以评估对增殖,入侵和迁移的影响.

主要成果:

在小鼠中,THS暴露显著增加了胃瘤发生率,并减少了无瘤存活率.
在小鼠和人类GC样本中确定了THS诱导的基因表达特征,其中SPP1和TRIB3是潜在的调解者.
暴露于THS增强了人体GC细胞的增殖,入侵和迁移在体外,与上皮介质转变 (EMT) 途径激活相关.

结论:

短期的THS暴露与胃癌的风险增加有关.
激活EMT通路是THS促进胃癌发生的潜在机制.
调查结果支持需要政策干预来控制THS污染并保护公共健康.

关键词:

CC036 鼠标的使用皮质 - 介质细胞过渡.胃癌是什么?胃癌是什么?基因表达签名基因表达签名第三手烟 (THS) 是指第三手烟.没有瘤的生存率.

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