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苏沃雷克桑提升了雄性大鼠的氧化诱导的呼吸抑制

Eliseu D C Moreira-Junior¹, James K Rowlett¹, Lais F Berro¹

¹Department of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Drug and alcohol dependence

|September 10, 2024

概括

苏沃雷克桑是一种双素受体对抗剂,在老鼠中恶化了阿片类药物诱导的呼吸抑制. 这凸显了将这些药物用于阿片类药物使用障碍和睡眠问题的组合时的潜在风险.

科学领域:

药理学药理学是指药理学的学科.
神经科学是一个神经科学.
呼吸系统生理学呼吸系统生理学

背景情况:

作为阿片类药物使用障碍 (OUD) 和相关睡眠问题,像suvorexant这样的双素受体对抗剂正在被探索.
素调节睡眠和清醒,成和呼吸功能.
与阿片类药物结合素抗剂可能会带来呼吸风险.

研究的目的:

为了研究单独和与氧化一起使用的suverexant对雄性大鼠的呼吸功能的影响.
为了评估结合素抗剂和阿片类药物的潜在不良呼吸道事件.

主要方法:

成年雄性斯普拉格·道利大鼠接受了车载剂,氧科或苏沃雷克桑.
通过全身囊造影 (plethysmography) 来记录呼吸系统的测量.
测试了苏沃雷克桑和氧化的组合.

主要成果:

氧化 (10mg/kg) 导致呼吸抑制;单独使用苏沃雷克桑并不影响呼吸.
结合了18mg/kg的suverexant和3mg/kg的oxycodone,显著降低了分钟和潮体积.
药物组合显著降低了呼吸频率.

结论:

在大鼠中,suvorexant增强了氧化诱导的呼吸抑制.
这种效应发生在与促进睡眠相关的剂量和阻断氧化自给的剂量时.
调查结果表明,由于呼吸系统风险,在使用suvorexant与阿片类药物时应谨慎使用.

关键词:

矿物质和矿物质 (Orexin和Orexin) 是一种有机物.氧化的氧化是什么?它们是老鼠,老鼠,老鼠.呼吸方式呼吸方式呼吸系统的抑郁呼吸系统的抑郁这是一种超级复杂剂 (suvorexant).

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