一个健康:城市鸟类会吸收耐药性病原体
Emma Derrick1, B Jesse Shapiro2
1Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.
Current biology : CB
|September 10, 2024
概括
城市化增加了病原体坎皮洛巴克特及其抗菌素耐药基因在靠近人类的鸟类物种的多样性. 这一发现凸显了野生动物和人类健康的潜在风险.
科学领域:
- 生态生态学 生态生态学
- 基因组学就是基因组学.
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 城市环境越来越被认为是疾病传播的热点.
- 城市化对野生动物病原体和抗菌素耐药性 (AMR) 的影响尚未完全理解.
- 鸟类种群是环境变化的敏感指标,可以作为病原体的储存库.
研究的目的:
- 调查与人类种群的接近与野鸟中Campylobacter及其AMR基因的多样性之间的关系.
- 评估城市化在鸟类野生动物中塑造病原体群落中的作用.
- 探索野生动物和人类之间的潜在传播途径.
主要方法:
- 在城市-农村梯度的野生鸟类中对野菌种群的空间基因组分析.
- 高通量测序用于表征病原体多样性和AMR基因配置文件.
- 统计建模以将鸟类与人类定居点的近距离与病原体特征相关联.
主要成果:
- 靠近人类定居点的鸟类表现出明显更高的Campylobacter多样性.
- 在城市附近的鸟类中,在Campylobacter中观察到抗菌素耐药性基因的增加和多样性.
- 空间基因组数据表明,在人类改变的景观中,病原体交换的可能性很大.
结论:
- 城市化是增加病原体多样性和野生动物抗菌素耐药性的驱动因素.
- 城市化地区的野生鸟类可以作为各种坎皮洛巴克特菌株的重要储存库,包括具有AMR基因的鸟类.
- 研究结果表明,在城市化生态系统中,野生动物和人类之间的病原体传播可能会增加.
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