巨细胞在表征系统性硬化症的渐进性纤维化中的干预:系统性审查
Rosanna Campitiello1, Stefano Soldano2, Emanuele Gotelli2
1Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialties (Di.M.I.), University of Genova, Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Autoimmunity reviews
|September 10, 2024
概括
系统性硬化症 (SSc) 涉及M2巨细胞的激活,导致纤维化. 准这些巨细胞显示出SSc治疗的治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 病理生理学 病理生理学
背景情况:
- 系统性硬化症 (SSc) 是一种免疫媒介疾病,其特点是微血管功能障碍,异常免疫力和纤维化.
- 由IL-4和TGF-β等细胞因子诱导的M2巨细胞在SSc的纤维化和抗炎过程中发挥作用.
- 了解M2巨细胞两极分化对于澄清SSc病原性至关重要.
结论:
- 在SSc中增加M2巨细胞激活提供了对自我增强的炎症和纤维性反应的见解.
- 重新评估免疫调节和抗纤维菌疗法,以及针对M2巨细胞的新方法,对于SSc治疗至关重要.
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