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基于paliperidone溶解和可植入的微阵列贴片的新型长效治疗精神分裂症
Li Zhao1, Linlin Li1, Eneko Larrañeta1
1School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
概括
新的微针贴片系统为精神分裂症治疗提供了改善的帕利佩里 (PPD) 输送. 这些患者施用的贴片提供持续的药物释放,增强坚持和减少医疗保健系统负担.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 精神分裂症的治疗依赖于非典型的抗精神病药物,如帕利佩里 (PPD).
- 目前的延长释放PPD注射需要专业的管理,影响了坚持和医疗保健资源.
- 微针贴片技术为改善药物输送和患者自我管理提供了潜力.
研究的目的:
- 开发和评估用于改善药物输送的新型帕利佩里 (PPD) 微阵列补丁 (MAP) 系统.
- 为了比较可溶解 (DMAP) 和可植入 (IMAP) PPD MAP 的性能.
- 评估患者自我管理和持续释放PPD的潜力.
主要方法:
- 开发了三种PPD MAP系统:PPD原药溶解MAP (PPD DMAP-CD),PPD纳米晶溶解MAP (PPD DMAP-NC) 和PPD原药植入式MAP (PPD IMAP). 这三种PPD MAP系统是:PPD原药溶解MAP (PPD DMAP-CD),PPD纳米晶溶解MAP (PPD DMAP-NC) 和PPD原药植入式MAP (PPD IMAP).
- 评估了机械和插入性能.
- 进行了体外释放,MAP溶解和体外皮肤输送研究.
主要成果:
- 所有PPD MAP都显示出出色的机械和插入性能 (>256μm深度).
- PPD IMAP提供持续释放长达14天的低初始爆发率 (20%),而DMAP在3分钟内溶解.
- 活体研究显示,PPD的释放量显著 (50-70%),IMAP释放时间最长,DMAP-NC释放时间最快.
结论:
- 帕利佩里 (PPD) 微阵列贴片 (MAP) 是持续抗精神病药物递送的有希望的替代品.
- 溶解 (DMAP) 和植入 (IMAP) 系统都能促进患者的自我管理和延长释放.
- 这些新型的MAP可能会提高患者的遵守率,并减少医疗保健系统的压力.
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