和多醇基物质 (PFAS) 和癌症:检测方法,流行病学见解,潜在的致癌机制,以及未来的前景
Jie Zheng1, Sheng Liu2, Junjie Yang3
1Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
The Science of the total environment
|September 10, 2024
概括
和多醇基物质 (PFAS) 或"永久化学品"是广泛存在的环境污染物. 本综述探讨了PFAS暴露与癌症风险之间的联系,强调了检测方法和流行病学证据.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 和多基基物质 (PFAS) 是自20世纪40年代以来广泛使用的持久合成化学品.
- 它们的热稳定性和化学惰性使得它们在消费品和工业过程中得到广泛应用.
- PFAS在全球分布,在人类和野生动物中检测到,引发了人们对毒性和致癌性的担忧.
研究的目的:
- 审查和综合有关PFAS暴露与癌症风险之间的关联的当前知识.
- 为突出PFAS检测方法的进步.
- 讨论流行病学发现和可能的机制,将PFAS与致癌症产生联系起来.
主要方法:
- 科学文献的审查,重点关注PFAS检测,流行病学和毒理学.
- 引入基于传感器和液态色谱-质谱 (LC-MS) 的检测技术.
- 对调查PFAS水平和癌症发病率的流行病学研究的分析.
主要成果:
- PFAS是无处不在的环境污染物,有记录的人类暴露.
- 流行病学研究表明,PFAS暴露与癌症风险增加之间存在潜在联系.
- 目前正在研究PFAS诱导的致癌机制.
结论:
- 进一步的研究对于阐明PFAS暴露与癌症之间的复杂关系至关重要.
- 拟议的4C原则为未来的研究方向提供了一个框架.
- 需要基于证据的策略来减轻与PFAS相关的健康风险.
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