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Updated: Jun 13, 2025

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs

Published on: June 12, 2018

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通过向生物发生与固体阻断抗意义寡核酸向生物发生来提高microRNA水平

Mallory A Havens1,2,3, Anthony J Hinrich4, Frank Rigo5

  • 1Center for Genetic Diseases, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA havensmy@lewisu.edu hastingm@umich.edu.

RNA (New York, N.Y.)
|September 10, 2024
PubMed
概括

研究人员开发了一种新的反感性寡核酸 (ASO) 策略,通过增强其生物生成来增加微RNA (miRNA) 水平. 这种方法成功地恢复了降低的miR-1225水平,为与miRNA失调相关的疾病提供了潜在的治疗途径.

关键词:
在PKD1中,PKD1是PKD1.反感的寡核化物.自体主导多囊性脏疾病这就是为什么miR-122525是miR-122525的.这是一个微型RNA.

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