来自MRI的腹部脂肪组织与多部位和广泛的慢性疼痛有关
Zemene Demelash Kifle1, Jing Tian1, Dawn Aitken1
1University of Tasmania Menzies Institute for Medical Research, Hobart, Tasmania, Australia.
Regional anesthesia and pain medicine
|September 10, 2024
概括
过多的腹部脂肪,包括内脏和皮下脂肪组织,与慢性肌肉骨疼痛有关. 这种联系在女性中更强烈,这表明脂肪沉积在疼痛发展中起着作用.
科学领域:
- 生物医学研究的研究.
- 流行病学 流行病学
- 疼痛科学是一种科学.
背景情况:
- 肌肉骨疼痛通常会影响多个身体部位.
- 之前的研究还没有研究过多的腹部脂肪和广泛的疼痛之间的联系.
- 这项研究探讨了腹部脂肪组织与慢性疼痛之间的关联.
研究的目的:
- 为了检查MRI量化的内脏和皮下脂肪组织与多站点/广泛的慢性肌肉骨疼痛之间的关系.
- 为了确定腹部脂肪是否与疼痛部位的数量有关.
- 探索这些关联中的潜在的性别差异.
主要方法:
- 利用了来自英国生物银行前性队列研究的数据.
- 使用MRI扫描量化腹部内脏和皮下脂肪组织.
- 评估了身体各个区域的疼痛和整体的疼痛.
- 使用混合效应回归模型进行统计分析.
主要成果:
- 包括32,409名参与者 (50.8%是女性,平均年龄为55.0岁).
- 发现了内脏脂肪组织,皮下脂肪组织,它们的比例,以及两性慢性疼痛部位的数量之间的剂量反应相关性.
- 较高的脂肪组织水平与报告慢性疼痛的概率增加相关,女性观察到的效果更强烈.
结论:
- 腹部脂肪组织与慢性肌肉骨疼痛显著相关.
- 过度和宫外脂肪沉积可能会导致多部位和广泛的慢性疼痛的发展.
- 在女性中更强烈的关联表明性别特异性脂肪分布和荷尔蒙因素的潜在作用.
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