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Updated: Jun 13, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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康提利桑特+图巴斯丁A杂交物:多功能性醇衍生物作为新的基于HDAC抑制剂的多目标小分子,在神经退行性疾病中具有In Vitro和In Vivo活动

Mireia Toledano-Pinedo1, Alicia Porro-Pérez1, Linda Schäker-Hübner2

  • 1Institute of General Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

Journal of medicinal chemistry
|September 10, 2024
PubMed
概括

结合Contilisant和Tubastatin A的新混合分子显示出作为强大的HDAC6抑制剂的希望. 这些化合物通过减少关键的病理特征,有效地改善了帕金森病和阿尔茨海默病的模型.

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