肝移植后恢复饮酒的心理社会预测因素:一个多中心队列研究
Kelly Torosian1, Bita Shahrvini2, Willie Mohammed Johnson3
1Division of Gastroenterology and Hepatology, University of California, San Diego, San Diego, California, USA.
Alcohol, clinical & experimental research
|September 10, 2024
概括
心理健康问题,而不是清醒的持续时间,预测肝移植 (LT) 后的酒精复发. 非西班牙裔白人患者在LT后回归酒精使用的风险更高.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植 移植 移植 移植
- 成 药物 药物 药物 药物
背景情况:
- 肝移植 (LT) 后使用酒精会增加移植损失和死亡率.
- 关于回归酒精使用的预测因素的数据有限,特别是使用生物化学标记物,如脂乙醇 (PEth).
研究的目的:
- 评估与酒精相关的肝病 (ALD) 患者在LT后回归酒精使用的心理社会预测因素.
- 评估PEth测试在识别患有酒精复发风险的患者中的有用性.
主要方法:
- 多中心回顾性队列研究,包括223名为ALD接受LT治疗的患者.
- 包括那些在LT后至少有一次PEth测量的患者.
- 评估了心理社会因素和PEth水平作为酒精使用的预测因素.
主要成果:
- 恢复使用酒精的比例为每100人/年6.9.
- 年龄较小,精神健康并发症和非西班牙裔白人种族与酒精复发风险增加有关.
- 在列入名单之前的清醒持续时间没有显著影响LT后的酒精使用或存活率.
- 非法物质使用史增加了LT后持续饮酒的几率.
结论:
- 精神健康并发症是LT后酒精复发的重要预测因素.
- 非西班牙裔白人与更高的风险有关,这表明患者选择或转诊的潜在差异.
- PEth测试可以帮助监测移植后的酒精使用情况.
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