毒理学调查人员联盟2023年年度报告
Adrienne Hughes1, Alexandra Amaducci2, Sharan L Campleman3
1Department of Emergency Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
概括
在2023年,乙醇成为美国医学毒理学学院 (ACMT) 毒理学调查者联盟 (ToxIC) 登记处报告的最常见的有毒暴露原因. 该注册表追踪了全国各地各种中毒病例的患者咨询情况.
科学领域:
- 毒理学 毒理学 毒理学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 美国医学毒理学学院 (ACMT) 毒理学研究人员联盟 (ToxIC) 核心注册表自2010年以来一直在收集有关患者咨询的全国数据.
- 该注册表捕获了被删除的患者信息,包括人口统计,暴露剂,临床表现,治疗方法和结果.
研究的目的:
- 提交第十四个年度报告的毒性IC核心注册表,详细介绍从2023年起的患者咨询.
- 分析暴露剂的趋势,咨询的原因和特定治疗结果.
主要方法:
- 数据来自2023年在36个参与站点 (61个医疗机构) 收集的7392次患者咨询.
- 对暴露剂类别的分析,根据年龄的咨询原因,以及特定暴露和治疗的趋势.
- 报告暴露的病例死亡率的计算.
主要成果:
- 乙醇是2023年最常见的暴露剂类别 (24.4%),这是自注册开始以来的第一次.
- 阿片类药物 (22.7%),非阿片类止痛药 (16.7%) 和抗抑郁药 (11.7%) 也是显著的暴露剂.
- 总体病例死亡率为1.3% (在7392例中有98例死亡).
结论:
- 乙醇已经成为报告到毒性物质登记处的毒性暴露的主要原因.
- 该注册表继续提供有价值的数据,以了解中毒趋势,并为医学毒理学实践提供信息.
- 进一步的分析强调了阿片类药物,精神活性药物和乙氨基暴露及其治疗的具体趋势.
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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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