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Updated: Jun 13, 2025

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
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RING1误解变体揭示了DNA损伤修复对神经发生过程中H2A单双化剂量敏感性

C W Ryan1,2,3, S L Regan3, E F Mills3

  • 1Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, USA.

Nature communications
|September 10, 2024
PubMed
概括

多镇压复合体1 (PRC1) 调节了H2AK119ub1.1. RING1变体影响神经前细胞中的DNA修复和细胞周期,而RNF2变体更广泛地影响基因表达.

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