设计一个用梅花提取物封装的多功能矩阵,以支持细胞功能,刺激原蛋白合成和减少伤口感染
Shahab Mohammadi1, Maryam Khavarpour2, Arezoo Ghadi1
1Department of Chemical Engineering, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
Scientific reports
|September 10, 2024
概括
使用三元技术的工程基板增强了马乔兰 (Origanum Majorana L.) 的封装. 这改善了物理化学特性,并通过控制释放草本生物活性物质来促进纤维细胞粘附和抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 开发先进的工程基板对于组织再生和治疗治疗至关重要.
- 梅花 (Origanum Majorana L.) 具有具有潜在治疗应用的生物活性化合物.
- 需要封装策略来稳定和控制这些生物活性物质的释放.
研究的目的:
- 评估不同基质设计技术对物理化学性质的影响.
- 评估将马生物活性封装到工程聚合物矩阵中的有效性.
- 为了研究封装大黄提取物的生物效应和释放动力学.
主要方法:
- 聚乙烯醇-聚乙烯甘醇 (PVA-PEG) 矩阵是使用冷解 (FT),冷干燥/冷解 (FT-FD) 和三元技术 (冷干燥,冷解,交联 - FT-FD/CL) 制造的.
- 梅花的生物活性被封装在优化的三元技术矩阵中.
- 分析了物理化学性质,封装效率,释放动力学,纤维细胞相互作用和抗菌活性.
主要成果:
- 三元技术 (FT-FD/CL) 产生了卓越的物理化学性能,包括96%的多孔性,降低了降解率和更高的模量.
- 封装效率提高,马乔兰提取物度高达3%,形成了一个更具凝聚力的矩阵.
- 释放动力学偏离了Fickian扩散,涉及扩散和胀. 负载矩阵增强了纤维细胞粘附,原蛋白合成,并表现出抗菌活性.
结论:
- 三元制造技术显著改善了用于生物活性封装的PVA-PEG矩阵特性.
- 封装的梅花提取物增强了工程基质的生物性能,促进了组织再生,并提供了抗菌效益.
- 优化封装和可控释放马乔兰的Epi-alpha-Cadinol和sesquiterpenoids是观察到治疗效果的关键.
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