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Updated: Jun 13, 2025

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
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在ICU中停止连续脏替代疗法后立即估计功能

T T Pieters1, M J van Dam2, M A Sikma2,3

  • 1Department of Nephrology and Hypertension, UMC Utrecht, Utrecht University, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.

Scientific reports
|September 10, 2024
PubMed
概括

在连续脏替代疗法 (CRRT) 后估计球透率 (eGFR) 对药物剂量至关重要. 一个新的动态肌素清除计算 (D3C) 方程有效地估计了CRRT后的eGFR,改善了重症监护室的患者管理.

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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
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Determination of Renal Drug Clearance: Graphical and Midpoint Methods

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Renal Clearance

The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
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Renal Drug Clearance: Comparison Between Renal Excretion Methods

Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
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