丁化物Rb1对肠道微生物群的影响以及与之相关的小鼠药理学变化
Yue Chen1, Kang-Xi Zhang2, Hui Liu2,3
1Master Lab for Innovative Application of Nature Products, National Center of Technology Innovation for Synthetic Biology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Scientific reports
|September 10, 2024
概括
丁胺Rb1口服显著改变了老鼠肠道微生物组合,影响了其药理动力学. 特定的肠道细菌和酶与人参酶Rb1和Rd暴露和清除的变化相关.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 金色化物Rb1具有多样化的生物活动.
- 肠道微生物群是人参胺Rb1代谢的主要部位.
- 肠道微生物群对金氏化物Rb1的药理动力学的确切影响尚不清楚.
研究的目的:
- 为了研究长期的金赛诺化物Rb1干预对肠道微生物组合的影响.
- 分析这些微生物组变化的影响,对人参胺Rb1及其代谢物Rd.的药理动力学.
- 为了确定参与金氏酸Rb1代谢的特定微生物和酶因素.
主要方法:
- 在30天内向大鼠口服金氏化物Rb1 (60毫克/公斤).
- 使用元基因组测序分析肠道微生物组合的分析.
- 药物动力学研究以确定全身暴露和代谢清除率.
- 微生物丰富度和药物动力学参数之间的相关性分析.
主要成果:
- 银化物Rb1的使用改变了Rb1和Rd的全身暴露和代谢清除.
- 观察到Bacteroides cellulosilyticus的相对丰度增加.
- 发现了特定的甘氨酸酸酶 (GH) 家族 (GH2,GH92,GH20) 的扩大.
- 在特定的Bacteroides物种,GH家族和人参素Rb1的药理学参数之间发现了强烈的关联.
结论:
- 丁化物Rb1的使用显著改变了大鼠的肠道微生物群.
- 肠道微生物群,特别是 Bacteroides cellulosilyticus 和特定的GH家族,在人参素Rb1的药理动力学中起着至关重要的作用.
- 这项研究阐明了肠道细菌,酶和人参化物Rb1代谢之间的复杂相互作用.
更多相关视频
08:28Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
Published on: December 14, 2021
8.1K
03:48Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research
Published on: March 1, 2024
1.2K
相关概念视频
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...