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Updated: Jun 13, 2025

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新生儿DNA甲基化年龄区分长期体重轨迹:波士顿出生队列

Anat Yaskolka Meir¹, Guoying Wang², Xiumei Hong²

¹Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

|September 10, 2024

概括

新生儿DNA甲基化年龄 (GAmAge) 预测了长期儿童超重或肥胖 (OWO) 轨迹,独立于妊娠年龄. 这种表观遗传标记可能有助于早期识别患有OWO风险的儿童.

科学领域:

健康和疾病的表观遗传学和发育起源 (DOHaD)
儿科内分泌学和肥胖研究
在生命早期发现生物标志物

背景情况:

通过新生儿DNA甲基化 (GAmAge) 估计的妊娠年龄与产前暴露和直接出生结果相关.
GAmAge与长期超重或肥胖 (OWO) 轨迹之间的关联仍在调查中.

研究的目的:

确定GAmAge是否与从出生到18岁的长期体重指数百分位数 (BMIPCT) 轨迹有关.
探索GAmAge作为预测OWO发展的潜在早期生物标志物.

主要方法:

从带血DNA甲基化概况计算的GAmAge来自美国出生队列的831名儿童.
使用重复的人类测量测量,定义了长期体重轨迹 (出生至18岁).
分析了GAmAge和BMIPCT轨迹之间的关联,并对共变量进行调整.

主要成果:

GAmAge区分稳定的正常重量轨迹和不稳定的轨迹与晚期或非常晚期OWO发展.
关联从出生到14岁是显著的,并且在调整妊娠年龄,母亲吸烟,分娩方式和孩子的性别后仍然存在.
出生体重调解了GAmAge对特定群体和年龄段OWO状态的影响.

结论:

GAmAge与从出生到18岁的BMIPCT轨迹有关,独立于妊娠年龄和出生体重.
GAmAge显示出作为预测BMI轨迹的早期生物标志物的潜力,并为OWO风险评估和预防策略提供信息.

关键词:

体重指数百分位数BMI百分位数基因表观时钟是什么?超重或肥胖的人群.儿科儿科儿科

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