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Updated: Jun 13, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

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与年龄相关的炎症酶激活的表征揭示了转录和转译后炎症反应的组织特异性差异

Sarah Talley1, Tyler Nguyen2,3, Lily Van Ye1

  • 1Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA.

Immunity & ageing : I & A
|September 10, 2024
PubMed
概括

衰老驱动慢性炎症,称为炎症,涉及炎症酶激活. 这项研究揭示了与年龄相关的炎症体的翻译后变化,不总是反映在基因表达中,影响各种组织.

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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

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Inflammatory Response01:28

Inflammatory Response

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Inflammation01:38

Inflammation

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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T Cell Types and Functions

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Regulation of the Unfolded Protein Response01:31

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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