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乳腺癌中的雄激素受体表达和临床特征

Dan-Dan Wang¹, Lin-Hong Jiang², Jian Zhang¹

¹Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Jiangsu, 210029, P. R, China.

World journal of surgical oncology

|September 10, 2024

概括

乳腺癌中的雄激素受体 (AR) 表达与较高的组织学级别和复发有关. AR阳性与特定的分子亚型相关,表明其作为AR阳性乳腺癌预后和向治疗的生物标记物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
临床病理学临床病理学

背景情况:

雄激素受体 (AR) 在包括乳腺癌在内的各种癌症中发挥作用.
了解AR表达模式对于预测乳腺癌预后和治疗反应至关重要.

研究的目的:

为了研究雄激素受体 (AR) 表达和乳腺癌患者的临床特征之间的关联.
确定AR表达是否可以作为乳腺癌亚型和结果的预测标记.

主要方法:

在2020年1月至2023年5月期间,对432名乳腺癌患者进行AR检测的临床记录的回顾性审查.
收集的数据包括年龄,更年期状态,TNM阶段,转移,PCR,组织学等级,ER,PR,Her-2,Ki-67和分子亚型.
进行了统计分析,以确定AR表达和这些临床参数之间的显著关系.

主要成果:

在87.27%的患者中检测到雄激素受体 (AR) 表达 (377/432).
AR表达与较高的组织学等级和瘤复发有显著的积极关联.
AR表达与分子亚型显著相关,包括雌激素受体 (ER),孕激素受体 (PR),Her-2,Ki-67和整体分子亚型分类. ER,PR,Her-2和瘤复发被确定为影响AR表达的独立风险因素.

结论:

雄激素受体 (AR) 表达是确定乳腺癌分子亚型的重要因素,可能表明预后较差.
AR阳性与独特的临床和分子特征有关,突出其作为AR阳性乳腺癌中新生物标志物和治疗点的潜力.

关键词:

雄激素受体的受体雄激素受体乳腺癌是什么? 乳腺癌是什么临床特征临床特征雌激素受体的受体是什么

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