患有多发性硬化症的人在行走,认知减去和认知运动双重任务期间,前极和后侧前额皮层的血液动力学
Felipe Balistieri Santinelli1,2, Renee Veldkamp1, Rodrigo Vitório3
1REVAL Rehabilitation Research Center, University of Hasselt, Hasselt, Belgium.
Neurorehabilitation and neural repair
|September 11, 2024
概括
患有多发性硬化症 (pwMS) 的人在行走时表现出较高的前极活动,表明步伐自动性降低. 这表明pwMS在双重任务期间的认知资源受限.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 康复科学 康复科学 康复科学
背景情况:
- 患有多发性硬化症 (pwMS) 的人在行走和双重任务时表现出皮质活动增加.
- 需要进一步调查前额叶皮层 (PFC) 在pwMS中地上行走期间的活动.
研究的目的:
- 检查在认知运动双任务 (DT) 期间的PFC活动及其在pwMS中的单个组件.
- 在pwMS中将神经活动与行为结果相关联.
主要方法:
- 功能近红外光谱 (fNIRS) 测量了前极和后侧PFC中的氧血球蛋白 (ΔHbO2) 和脱氧血球蛋白 (ΔHHb).
- 参与者包括15个 pwMS和16个健康对照 (HC) 执行单步 (SWT),单认知任务 (SCT) 和DT条件.
- 重复的双向ANOVA分析了组和条件对血液动力学反应和行为结果的影响.
主要成果:
- 在所有条件下,PwMS比HC走得更短的距离,回答的认知问题比HC少.
- 双重任务成本 (cDTC,mDTC) 在各组之间是可比的.
- 在SWT期间,PwMS显示前极 ΔHbO2 比HC高,而HC在SCT和DT期间增加了前极 ΔHbO2.
结论:
- 在SWT期间pwMS中前极活动升高表明步行自动性受损.
- 在认知任务期间,pwMS缺乏增加的前极活动,表明双重任务的认知资源的潜在局限性.
相关概念视频
Disorders of the Autonomic Nervous System
1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.9K
Imbalances in Cardiac Output
3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
773
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
773
Peripheral Artery Disease V: Postoperative Nursing Management
637
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
637
Healing II: Complications
39
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
39
Multiple Sclerosis l: Introduction
32
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
32


