乳腺癌的辅助和新辅助疗法:系统性审查
Amal Sayfuldeen Qari1, Ali Hussain Mowais2, Sultan Mohammed Alharbi2
1Taibah University Faculty of Medicine Medina, Saudi Arabia.
European journal of breast health
|September 11, 2024
概括
本综述检查了新辅助和辅助乳腺癌 (BC) 疗法,发现大多数降低死亡率. 然而,抗环素化疗和放射治疗增加了非BC死亡人数,影响了患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 临床医学 临床医学
- 系统审查是系统的审查.
背景情况:
- 乳腺癌 (BC) 是女性最常见的癌症.
- 新辅助治疗是在手术前进行的,辅助治疗是在手术后进行的.
- 了解这些疗法对患者治疗结果的影响至关重要.
研究的目的:
- 系统地审查新辅助和辅助乳腺癌治疗对患者结局和死亡率的影响.
- 确定影响患者生活质量的因素.
- 根据疗效和风险提供治疗建议.
主要方法:
- 系统的文献搜索于2023年7月在主要数据库 (科克兰图书馆,科学网,谷歌学者,EMBASE,PubMed) 进行.
- 包括专注于第一,第二和第三阶段乳腺癌的研究,不包括转移或复发的病例.
- 使用Cochrane风险偏差技术进行的偏差风险评估.
主要成果:
- 分析了27项涉及161,552名患者的研究.
- 推的治疗方法包括抗HER2疗法,抗环素化疗,内分泌疗法,双酸盐和各种放射治疗选择.
- 虽然大多数治疗方法可以降低BC死亡率/复发率,但抗胰岛素,化疗和放射治疗增加了非BC死亡率.
结论:
- 新辅助和辅助疗法在减少乳腺癌死亡率和复发方面具有显著的好处.
- 某些治疗方法,特别是人环素化疗和放射治疗,与非BC死亡率的增加有关,需要仔细考虑风险和益处.
- 治疗决策应该是个性化的,平衡有效性与对生活质量的潜在不良影响.
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