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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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相关实验视频

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Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
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多个细胞死亡模式和脉炎的免疫反应.

Ben Wang1,2,3, Wenwen Li1,2,3, Weiying Huang1,2,3

  • 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China.

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胸膜炎涉及不同的细胞死亡模式,其中中性粒细胞外细胞陷 (NETosis) 特别是在部区域. 胸膜炎也会增加骨髓中性粒细胞的活动,这表明潜在的诊断策略针对NETs.

关键词:
网症 (NETosis) 是一种疾病.中性粒细胞中性粒细胞.这就是pulpitis.脉与死亡缩在一起.没有亡的脉.调节的细胞死亡.

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科学领域:

  • 口腔生物学 口腔生物学
  • 免疫学 免疫学 免疫学
  • 细胞病理学细胞病理学

背景情况:

  • 牙髓炎 (pulpitis) 是牙髓的炎症状况,可以发展为亡,显著影响牙活力.
  • 调节细胞死亡 (RCD) 途径,包括亡,烧亡,亡和NETosis,都与炎症过程有关,但它们在脉病中的独特作用尚未完全阐明.

研究的目的:

  • 调查人类脉中亡和没有亡的apoptosis,pyroptosis,necroptosis和NETosis的差异表达和分布.
  • 在小鼠模型中评估脉与亡 (PWN) 对外围和骨髓 (BM) 中性粒细胞以及脏淋巴细胞的全身影响.

主要方法:

  • 人类牙纸的组织学分类为健康的纸 (HP),没有亡的纸 (PWON) 和有亡的纸 (PWN).
  • 针对RCD标记物的免疫组织化学和免疫光染色 (caspase-8,裂开的caspase-3,caspase-1,气体皮质D,RIPK3,MLKL,MPO,素基因组H3).
  • 在小鼠中诱导脉炎,然后进行中性粒细胞和淋巴细胞的流动细胞计分析,以及对人类牙髓干细胞 (hDPSCs) 的体外研究.

主要成果:

  • 松鼠菌表现出明显更高的总死细胞水平,亡,烧亡,尤其是NETosis,特别是在腹核心.
  • 骨髓氧化酶 (MPO) 是NETosis的标志物,主要存在于PWN的核中.
  • 在小鼠中诱导脉炎增加了骨髓中性粒细胞的数量和活性,而周围血液和脏淋巴细胞人群保持不变.

结论:

  • 混合调节细胞死亡的不同模式发生在脉炎的不同组织学阶段.
  • 网是皮炎腹部的特定和主要特征,表明它在疾病进展中的作用.
  • 观察到的骨髓中性粒细胞的变化突出显示了对脉的系统性免疫反应,而NETosis可能会在重要脉治疗中提供诊断策略的目标.