胃神经内分泌瘤的分类和与生存的关联
Yun Song1, Eunise Chen2, Yi-Ju Chiang1
1Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Journal of surgical oncology
|September 11, 2024
概括
与质子抑制剂 (PPI) 相关的胃神经内分泌瘤 (GNETs) 可能是具有中间结果的独特亚型. GNET亚型,种族和远程转移独立地影响疾病特异性生存率.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 胃神经内分泌瘤 (GNETs) 通常分为三个临床病理学亚型.
- 一些GNET不符合既定分类,需要进一步的表征.
研究的目的:
- 为了更好地描述GNET亚型,包括那些不符合标准分类的亚型.
- 调查与不同GNET亚型相关的结果.
主要方法:
- 在1995年至2021年期间接受治疗的246名GNET患者的回顾性评估.
- 对未分类的GNET进行病理性重新评估,确定与质子抑制剂 (PPI) 相关的亚型.
- 远程转移 (DM) 在呈现和疾病特异性存活率 (DSS) 的分析.
主要成果:
- 确定了18个 (7%) 与PPI相关的GNET,以及1型 (67%),2型 (2%) 和3型 (21%) 的瘤.
- 与PPI相关的 (11%) 和其他亚型相比,远程转移在3型GNET中更频繁 (38%).
- 十年DSS率有所不同:类型1的百分之百,与PPI相关的80%,类型3的53%.
结论:
- 与PPI相关的GNET可能代表一种具有中间预后的独特亚型.
- GNET亚型,种族和远程转移的存在是疾病特异性生存的独立预测因素.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
154
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
154
Hormones Secreted by the Stomach
439
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
439
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334


