选择放射治疗的可以通过手术切除的肺癌患者的结果更糟
Kimberly J Song1, Isaac Faith1, Stephanie Tuminello1
1Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York, USA.
Journal of surgical oncology
|September 11, 2024
概括
对于早期的肺癌,手术切除为符合两种治疗条件的患者提供了比放射治疗更好的生存率. 放射治疗对于那些无法接受手术的人来说是有效的.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 辐射瘤学 辐射瘤学
背景情况:
- 手术是可切除原发性肺癌 (LC) 的标准治疗方法.
- 立体体辐射疗法 (SBRT) 是一种替代方案,但结果数据因患者选择而有偏见.
- 这项研究比较了手术和放射治疗之间的存活率,这些患者有资格接受这两种手术.
研究的目的:
- 为了比较早期非小细胞肺癌 (NSCLC) 患者的生存结果,这些患者接受了手术切除,而不是那些选择放射治疗的人.
- 评估SBRT与手术相比在切除初级LC患者中的疗效.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库,用于I期NSCLC患者 (2007-2016).
- 排除了未知外科推或禁忌的患者.
- 进行多变量分析并生成卡普兰-梅尔生存曲线,调整年龄,性别,种族,保险,婚姻状况,瘤大小和组织学.
主要成果:
- 与放射治疗相比,手术切除显示了显著更高的生存率 (调整HR为2.66,p<0.001).
- 接受手术的患者的生存率也比未接受标准化治疗的患者要好 (调整HR为4.43,p<0.001).
结论:
- 与放射治疗相比,手术切除是可切除的早期肺癌患者的优越治疗方式.
- 对于无法进行手术的患者来说,SBRT仍然是一个有效的选择,但比较数据强调了手术对符合条件的候选人的优势.
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