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乳腺HER2阳性1级侵袭性乳腺癌
Andrew H S Lee1, Zsolt Hodi1,2, Areeg Abbas1
1Histopathology Department, Nottingham University Hospitals, City Hospital Campus, Nottingham, UK.
Histopathology
|September 11, 2024
概括
HER2阳性1级乳腺癌很少见,通常表现出核形和负激素受体状态等特定特征. 在大多数情况下,重复测试证实了HER2阳性结果.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 美国临床瘤学会和美国病理学家学院的HER2指南建议在核心活检中重复检测HER2阳性1级乳腺癌.
- HER2阳性1级癌瘤的组织学特征需要进一步调查.
研究的目的:
- 评估在1级乳腺癌中重复HER2测试的有用性.
- 为了确定与HER2-阳性1级乳腺癌相关的组织学特征.
主要方法:
- 在5年的时间里,对1级乳腺癌的HER2检测结果进行了病例系列分析.
- 最初报告的HER2阳性1级癌瘤的组织学综述.
- 在HER2-阳性和HER2-阴性等级1癌症之间的组织学特征的比较.
主要成果:
- HER2阳性1级癌症不常见,占所有1级癌症的2%.
- 阳性HER2的1级癌瘤更频繁地表现出明显的核形 (50%vs. 6%) 并更频繁地对雌激素受体阴性 (17%vs. 0.8%) 和孕激素受体阴性 (28%vs. 8%).
- 重复测试证实了13例中11例 (85%) 的HER2阳性结果.
结论:
- HER2-阳性1级乳腺癌是罕见的,并且与HER2-阴性乳腺癌不同,原因是核形的增加和激素受体表达的丧失.
- 重复HER2测试对于确认1级乳腺癌的核心活检中HER2阳性结果是有价值的.
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