危急病重症成年人格兰氏阴性细菌病的阳性随访血液培养的危险因素
Rebecca A Mayes1, Emily A Siegrist1, Julia Mathew1
1University of Oklahoma Medical Center at OU Health, Department of Pharmacy, Oklahoma City, OK, USA.
JAC-antimicrobial resistance
|September 11, 2024
概括
随访血液培养 (FUBCs) 有助于识别ICU患者的重复性格兰氏阴性血流感染 (BSI). 缺乏源控制和更短的FUBC时间增加了积极结果的风险.
科学领域:
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
- 临床微生物学 临床微生物学
背景情况:
- 格拉姆阴性血流感染 (BSI) 是重症监护室 (ICU) 的一个重大问题.
- 需要进一步调查的实用性和风险因素为积极的随访血液培养 (FUBCs) 在严重病患者的格兰阴性BSI.
研究的目的:
- 评估FUBCs在ICU患者中检测持续的グラム阴性BSI的临床实用性.
- 确定与重复阳性FUBCs相关的患者特异性和治疗相关的风险因素.
主要方法:
- 一项回顾性队列研究对严重病重的成年患者进行,这些患者患有格拉姆阴性BSI.
- 数据从2015年1月到2020年1月收集,包括患者人口统计,生物体识别和FUBC结果.
- 进行统计分析,包括单变量和多变量回归,以确定风险因素.
主要成果:
- 在148名患者中,42名 (28.4%) 患者至少有一例FUBC阳性.
- 常见的病原体包括大肠杆菌和肺炎克莱布西拉.
- 阳性FUBC的危险因素包括MDR生物,免疫功能低下状态,发烧,血管压缩剂使用,缺乏源控制,以及从索引到FUBC的时间较短.
结论:
- 缺乏源控制和初始和随访血培之间的较短间隔是重复阳性FUBC在ICU患者的显著预测因素.
- 需要进一步的前性研究来确定FUBCs在管理这些感染中的最佳作用.
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