接种mRNA-1273疫苗诱导多功能记忆CD4和CD8T细胞响应在接受免疫治疗和/或化疗的固体癌症患者
Anastasia Gangaev1, Yannick van Sleen2, Nicole Brandhorst1
1Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Frontiers in immunology
|September 11, 2024
概括
癌症患者的COVID-19疫苗接种诱导了强大的T细胞反应. 系统性癌症治疗不会损害这些疫苗诱导的T细胞反应的质量,支持对固体瘤患者的疫苗接种.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在癌症患者中,SARS-CoV-2疫苗接种是安全有效的.
- 癌症治疗对疫苗诱导的T细胞免疫力的影响尚未完全理解.
研究的目的:
- 评估在接受各种癌症治疗的固体瘤患者中对mRNA-1273疫苗的功能和表型T细胞反应.
- 将这些反应与没有癌症的个体的反应进行比较.
主要方法:
- 在386名参与者中评估尖端特异性T细胞反应的ELISpot试验.
- 流细胞计分析63名参与者的T细胞表型和功能.
主要成果:
- 在所有治疗组中观察到强大的尖端特异性T细胞反应 (75-80%).
- 在接种疫苗的患者和对照人群中,可比的多功能记忆T细胞反应.
- 免疫治疗患者表现出扩张的CD4 T细胞,具有终端分化效应记忆表型.
结论:
- 系统性癌症治疗不会影响mRNA-1273疫苗诱导的T细胞反应的质量.
- 对于接受全身治疗的固体瘤患者来说,COVID-19疫苗接种至关重要.
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