在Streptococcus pneumoniae的细菌病中,抗生素持续时间短或长
Matthew Crotty1, Hadley Devall1, Natalie Cook1
1Department of Pharmacy, Methodist Dallas Medical Center, Dallas, Texas, USA.
Open forum infectious diseases
|September 11, 2024
概括
较短的抗生素持续时间 (5-10天) 与较长的疗程 (11-16天) 同样有效治疗Streptococcus pneumoniae bacteremia,特别是在肺炎的次要情况下. 这一发现支持降低抗生素治疗的升级.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺炎链球菌 (Streptococcus pneumoniae) 是一个重要的病原体,引起各种感染,包括血液感染.
- 有限的数据存在于最优的抗生素治疗时间的S. pneumoniae细菌性二次常见感染.
- 这种变异性需要研究有效的,较短的抗生素疗程.
研究的目的:
- 为了评估短 (5-10天) 与长 (11-16天) 的抗生素持续时间对S. pneumoniae bacteremia的有效性.
- 为了比较不同抗生素治疗持续时间之间的临床失败率.
主要方法:
- 回顾性,单中心队列研究住院患者的S. pneumoniae bacteremia.
- 纳入标准:阳性血液培养,在48小时内使用活性抗生素,在第10天临床稳定性.
- 排除标准:治疗时间少于5天或长于16天,在第10天之前死亡,多微生物感染.
主要成果:
- 包括162名患者:51名在短期治疗组,111名在长期治疗组.
- 两组之间临床失败率 (再入院,复发,死亡率) 没有显著差异.
- 在90%以上的病例中,肺炎是病因;在LOS或C. difficile感染率上没有显著差异.
结论:
- 较短的抗生素疗程 (5-10天) 对于S. pneumoniae细菌性二次性和社区获得的肺炎是有效的.
- 研究结果表明,在某些特定情况下,降低抗生素治疗的程度可能是适当的.
- 进一步的研究可以完善在S. pneumoniae bacteremia中抗生素持续时间的指导方针.
更多相关视频
09:12Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
12.4K
09:26Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
6.9K
相关概念视频
01:28Pulmonary Tuberculosis V
172
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
172
01:30Pneumonia I: Introduction
214
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
214
01:20Sputum Studies II: Culture and Sensitivity
271
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
271