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在COVID-19症状患者中,外周血液粒细胞的MDS型形态异常

Mohammad Jafar Sharifi^1,2, Negar Gheibi³, Fatemeh Panahi¹

¹Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

International journal of hematology-oncology and stem cell research

|September 11, 2024

概括

COVID-19 感染可以导致粒细胞的骨髓质疏松症候群 (MDS) 样变化. 这些发现凸显了考虑COVID-19在无法解释的粒细胞扩张不良的患者的重要性.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

COVID-19 感染呈现出各种血液学异常.
骨髓质疏松症候群 (MDS) 的诊断依赖于异常的血液学发现和不整形形态.
病毒感染是导致失塑形态的潜在原因,需要被形态学家考虑.

研究的目的:

在有症状的COVID-19患者中表征粒细胞系形态异常.
为了研究COVID-19感染和骨髓质疏松症候群 (MDS) 类变化之间的相关性.
澄清COVID-19中观察到的异位形成形态的诊断含义.

主要方法:

在外周血液涂抹中对粒细胞血统的形态检查.
该研究包括82名具有症状的RT-PCR确诊的COVID-19患者.
使用了标准的赖特-吉姆萨染色和专家显微镜评估.

主要成果:

观察到的MDS类型异常包括伪佩尔格核分泌 (4.8%),低分泌 (7.3%),豪威尔-乔利体 (6.0%) 和异常核纤维 (6.0%).
一个病例表现出异常的不成熟粒细胞和环状细胞核.
这些失塑性变化在有症状的COVID-19患者中被发现.

结论:

在呈现颗粒细胞失生症的患者中,应考虑活跃的COVID-19感染.
这些发现对于诊断骨髓质疏松症候群 (MDS) 和骨髓质恶性瘤具有实际意义.
这项研究强调了COVID-19诱导骨髓质疏松变化的潜力.

关键词:

在 COVID-19 疫情中,颗粒细胞颗粒细胞形态学形态学形态学骨髓质疏松症候群 (MDS) 是一种疾病.周围血液周围血液

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