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Updated: Jun 13, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
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突变CHCHD2的小鼠显示线粒体蛋白质的积累和能量代谢的破坏

Szu-Chi Liao1,2,3,4, Kohei Kano1,4, Sadhna Phanse5

  • 1Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA.

bioRxiv : the preprint server for biology
|September 11, 2024
PubMed
概括

具有CHCHD2突变的小鼠显示线粒体破坏和转向糖解,模仿帕金森病 (PD) 机制. 这项研究建立了一个新的PD模型,涉及呼吸链功能障碍.

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相关概念视频

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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