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Updated: Jun 13, 2025

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协调Tbx3/Tbx5成年心室导电系统的转录控制

Ozanna Burnicka-Turek1, Katy A Trampel2, Brigitte Laforest1

  • 1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.

bioRxiv : the preprint server for biology
|September 11, 2024
PubMed
概括

T-box转录因子TBX3和TBX5对于心脏的电气系统至关重要. 它们的联合缺失会扰乱心脏导电,导致心律失常和细胞身份改变,影响人类对心脏病的理解.

关键词:
T-box转录因子的转录因子在Tbx3中使用.Tbx3:Tbx5 双条件鼠标线路Tbx3:Tbx5缺乏的小鼠在Tbx5中使用.节律失常 节律失常心脏导电系统 (CCS) 是一种心脏导电系统.心脏模式的形成心脏节奏 节奏 心脏节奏通过对VCS进行重新编程.腹腔导电系统 (VCS) 是一种心室导电系统.

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