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Updated: Jun 13, 2025

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
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Published on: December 10, 2021

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致病性人类亨廷丁蛋白在神经系统的发育和生理影响

Tadros A Hana, Veronika G Mousa, Alice Lin

    bioRxiv : the preprint server for biology
    |September 11, 2024
    PubMed
    概括

    亨廷顿病 (HD) 模型显示,亨廷顿蛋白 (htt) 聚合会导致运动缺陷和寿命缩短. 拉帕米辛在表达病原性HTT的中部分挽救了寿命,提供了治疗洞察力.

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