与太空相关的并发症和有影响的周围操作因素OAR水凝放置
Kerith R Wang1,2, Rishabh K Simhal1,3, Cassra B Clark1,4
1Department of Urology Sidney Kimmel Medical College Thomas Jefferson University, Philadelphia, PA, USA.
用于前列腺癌放射治疗的SpaceOAR水凝放置通常耐受良好,轻微并发症的发生率很低. 以前的激素治疗可能会降低并发症的风险.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 太空OAR水凝用于减少前列腺放射治疗期间的直肠毒性.
- 了解SpaceOAR安置并发症对于质量改进至关重要.
研究的目的:
- 评估SpaceOAR安置经验,并发症和影响因素在一个学术机构.
- 确定影响SpaceOAR质量改进结果的周边程序特征.
主要方法:
- 在2018-2021年期间接受SpaceOAR的233名患者的回顾性评估.
- 分析患者的人口统计,瘤参数,辐射计划和水凝放置情况.
- 查尔森并发症指数 (CCI) 用于并发症风险评估.
- 曼-惠特尼和费舍尔对并发症的确切测试进行比较.
主要成果:
- 10.3%的患者出现了轻微的过渡性并发症 (Clavien I或II).
- 在6.9%的患者中,直肠壁注射了水凝,但没有临床意义.
- 医生体积显示了不同的并发症率 (4.2%至16.2%).
- 以前的激素治疗与更少的并发症有关 (多变量分析).
结论:
- 太空OAR水凝布置耐受性良好,毒性低.
- 主治医生和先前的激素治疗是并发症发生率的重要因素.
- 这些发现支持太空OAR程序的质量改进倡议.
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